Monday Night Football Odds 2025: Full MNF Schedule & Odds
The Chicago Bears will host the rival Minnesota Vikings in the season's first edition of Monday Night Football on ESPN, and the Bears are 1.5-point betting favorites by the opening NFL Week 1 odds.
The 2025 Monday Night Football schedule begins with a bang and this clash of this NFC North rivals. Bears head coach Ben Johnson will get his introduction against a team he already knows well from his days with the Detroit Lions.
There'll be 21 Monday Night Football games throughout the season, with doubleheaders in each of Weeks 2, 4, 6, and 7. We have the NFL schedule and opening odds for each of those matchups.
🗓️ Monday Night Football 2025 schedule
Opening Monday Night Football odds for the 2025 season regular season are via DraftKings.
| Week | Matcup | Spread | Over/Under |
|---|---|---|---|
| 1 (Sept. 8) | Vikings vs. Bears | Bears -1.5 | 45.5 |
| 2 (Sept. 15) | Buccaneers vs. Texans | Texans -1.5 | 46.5 |
| 2 (Sept. 15) | Chargers vs. Raiders | Chargers -3 | 44.5 |
| 3 (Sept. 22) | Lions vs. Ravens | Ravens -3.5 | 49.5 |
| 4 (Sept. 29) | Jets vs. Dolphins | Dolphins -5.5 | 44.5 |
| 4 (Sept. 29) | Bengals vs. Broncos | Broncos -2.5 | 47.5 |
| 5 (Oct. 6) | Chiefs vs. Jaguars | Chiefs -4.5 | 47.5 |
| 6 (Oct. 13) | Bills vs. Falcons | Bills -5.5 | 48.5 |
| 6 (Oct. 13) | Bears vs. Commanders | Commanders -4.5 | 48.5 |
| 7 (Oct. 20) | Buccaneers vs. Lions | Lions -3.5 | 49.5 |
| 7 (Oct. 20) | Texans vs. Seahawks | Seahawks -1.5 | 44.5 |
| 8 (Oct. 27) | Commanders vs. Chiefs | Chiefs -3.5 | 48.5 |
| 9 (Nov. 3) | Cardinals vs. Cowboys | Cowboys -1.5 | 47.5 |
| 10 (Nov. 10) | Eagles vs. Packers | Eagles -1.5 | 45.5 |
| 11 (Nov. 17) | Cowboys vs. Raiders | Cowboys -1.5 | 45.5 |
| 12 (Nov. 24) | Panthers vs. 49ers | 49ers -7 | 46.5 |
| 13 (Dec. 1) | Giants vs. Patriots | Patriots -3 | 42.5 |
| 14 (Dec. 8) | Eagles vs. Chargers | Eagles -2.5 | 45.5 |
| 15 (Dec. 15) | Dolphins vs. Steelers | Steelers -2.5 | 44.5 |
| 16 (Dec. 22) | 49ers vs. Colts | 49ers -3 | 46.5 |
| 17 (Dec. 29) | Rams vs. Falcons | Rams -3 | 46.5 |
Don't miss our lists of the best NFL parlay betting sites and top NFL prop betting sites!
MNF Week 1 odds: Vikings vs. Bears (-1.5)
Ben Johnson's Bears are 1.5-point favorites at Soldier Field in Week 1. QB Caleb Williams lost twice to the Vikings as a rookie, but Chicago took it to overtime at home in the first meeting before losing 30-27 at home. Williams threw for 340 yards in that first head-to-head matchup.
This line could shift heavily to Minnesota if Chicago is unimpressive during preseason with its first-year head coach.
🧠 Monday Night Football betting tips
Get an early start
The Monday Night Football game is a big deal for betting each week. This brings lots of bets and changes in the odds, especially from those chasing their losses after a tough Sunday betting slate. Watch the lines and totals when they start. If they go the way you like, you can wait. If they move against you, think about acting sooner.
Embrace in-game betting
While you might struggle to find value in the most popular markets for any marquee prime-time NFL game, you're sure to unearth some worthwhile plays once the game starts. Live betting might not be your thing when there are a handful of games going on at the same time, but Monday Night Football is the perfect time to lay into some live action via our best live betting sites.
Be wary of winter weather
Things can get pretty frightful outside later in the NFL season – particularly when the sun goes down. Our guide on how to bet on the NFL offers tips for how to approach betting on cold-weather games.
Check out our list of the best sportsbook promos here!
❓Monday Night Football FAQs
Who will make the most Monday Night Football appearances in 2025?
No team will make more than two appearances on Monday Night Football season.
How do I watch Sunday Night Football?
Monday Night Football is broadcast on ESPN with some doubleheaders appearing on ABC.
🏟️ NFL betting odds pages
💵 Best NFL betting sites
Ready to bet on the NFL this season? Check out our best NFL betting sites and the best sportsbook promos for the 2025-26 NFL season:
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